With the recent FDA approval of Lumason (Sonovue), we seem to now have a third option for CEUS. Is anyone planning to switch agents?
My interest is primarily abdominal imaging. I understand Sonovue is very popular in Europe and Asia for these applications but I haven't yet seen any data showing diagnostic advantage over Definity or Optison. Does anyone have any experience with this?
University of Wisconsin Radiology
it works pretty much the same as Definity or Optison. Practically no difference.
I currently use Definity, mainly use it for liver imaging. I could do several injections out of one vial if needed. Lumason will be 5ml after reconstitution. You can do 2-3 injections. I do not know the cost of Lumason, if any difference. I am assuming it would be about the same cost as Optison and Definity? Anybody knows?
University of California, San Diego
I think the biggest difference is that Sonovue/Lumason can be hand-agitated vs. needing to use the Vialmix with Definity.
Cost really depends on your contract but if I remember correctly Definity's list price might currently be lower (please correct me if I am wrong).
Sonovue certainly has been studied more extensively outside the US in non-cardiac applications. Not sure if anyone has ever done a head-to-head comparison. In my mind they probably both get the job done.
Mayo Clinic, Rochester